Yes, you can wear your single cuff opened as an alternative to vary. If, it is that kind of detail that is very much you. If not, just keep on wearing it closed.
But if it is for you, then be aware that you can wear it opened with a blazer, a coat, a jacket or a cardigan framing it for you. Or you can wear a shirt with an opened cuff with nothing over it. That is another possibility.
This will give a stylish fashion forward touch to your look. And yes, it is a bit more casual, but still a possibility to wear with a suit even. It will all depends on you, your style and whether or not the occasion would welcome that little detail. Detail that can make a difference.